Alginic Acid Specifications of Commercial Pure & BP Ph Eur USP NF FCC Food Grade Manufacturers & Exporters
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Alginic Acid CAS Number 9005-32-7
Alginic Acid USP NF Grade Specifications:
(C6H8O6)n
Alginic acid CAS 9005-32-7
DEFINITION
Alginic Acid is a hydrophilic colloidal carbohydrate extracted with dilute alkali from various species of brown seaweeds (Phaeophyceae).
IDENTIFICATION
A.
Analysis: To 5 mL of a 1-in-150 solution in 0.1 N sodium hydroxide add 1 mL of calcium chloride.
Acceptance criteria: A voluminous, gelatinous precipitate is formed.
B.
Analysis: To 5 mL of a 1-in-150 solution in 0.1 N sodium hydroxide add 1 mL of 4 N sulfuric acid.
Acceptance criteria: A heavy, gelatinous precipitate is formed.
C.
Analysis: To 5 mg in a test tube add 5 mL of water, 1 mL of a freshly prepared 1-in-100 solution of 1,3-naphthalenediol in alcohol, and 5 mL of hydrochloric acid. Heat the mixture to boiling, boil gently for 3 min, then cool to 15 c. Transfer the contents of the test tube to a 30-mL separator with the aid of 5 mL of water, and extract with 15 mL of isopropyl ether.
Acceptance criteria: The isopropyl ether extract exhibits a deeper purplish hue than that from a blank, similarly prepared.
Arsenic: NMT 3 ppm
Lead:
Standard solution: 5 mL of Diluted Standard Lead Solution
Test preparation: Add 1.0 g to 20 mL of nitric acid in a 250-mL conical flask, mix, and heat carefully until the Alginic Acid is dissolved. Continue heating until the volume is reduced to 7 mL. Cool rapidly to room temperature, transfer to a 100-mL volumetric flask, and dilute with water to volume.
Analysis: Use 50.0 mL of the Test preparation, and proceed as directed in the chapter, using 15 mL of ammonium citrate solution, 3 mL of potassium cyanide solution, and 0.5 mL of hydroxylamine hydrochloride solution. After the first dithizone extraction, wash the combined chloroform layers with 5 mL of water, discarding the water layer and continuing in the usual manner by extracting with 20 mL of 0.2 N nitric acid.
Acceptance criteria: NMT 5 µg of lead (corresponding to NMT 10 ppm)
Microbial Enumeration Tests and Tests for Specified Microorganisms: The total aerobic microbial count does not exceed 2 x 102 cfu/g, and the tests for Salmonella species and Escherichia coli are negative.
pH: 1.5 to 3.5, in a 3-in-100 dispersion in water
Loss on Drying: Dry a sample at 105C for 4 h: it loses NMT 15.0% of its weight.
Articles of Botanical Origin, Total Ash:
Sample: 4 g of Alginic Acid
Analysis: Proceed as directed in the chapter, carefully igniting the Sample in a tared platinum dish, until the residue is thoroughly carbonized (5 min). Then ignite in a muffle furnace at a temperature of 800±25C until the carbon is completely burned off (20 to 35 min).
Acceptance criteria: NMT 4.0% of ash
Fats and Fixed Oils, Acid Value:
Sample: 1 g of Alginic Acid
Analysis: Suspend the Sample in a mixture of 50 mL of water and 30.0 mL of calcium acetate solution (11 in 250). Shake thoroughly, allow the mixture to stand for 1 h, and add phenolphthalein TS. Titrate the liberated acetic acid with 0.1 N sodium hydroxide. Perform a blank determination, and calculate the Acid Value:
Result = [(V S - V B) x N x F]/W
V S = volume of 0.1 N sodium hydroxide consumed in the titration of the Sample (mL)
V B = volume of 0.1 N sodium hydroxide consumed in the titration of the blank (mL)
N = normality of sodium hydroxide (mEq/mL)
F = equivalency factor of potassium hydroxide, 56.11 (mg/mEq)
W = weight of Alginic Acid taken (g)
Acceptance criteria: NLT 230 on the dried basis
Packaging and Storage: Preserve in well-closed containers.
Specifications of Alginic Acid BP Ph Eur Grade:
Action and use: Treatment of gastro-oesophageal reflux disease; excipient; thickening agent.
DEFINITION
Mixture of polyuronic acids [(C6H8O6)n] composed of residues of d-mannuronic and l-guluronic acids, obtained mainly from algae belonging to the Phaeophyceae. A small proportion of the carboxyl groups may be neutralised.
Content: 19.0 per cent to 25.0 per cent of carboxyl groups (-CO2H) (dried substance).
CHARACTERS
Appearance: White or pale yellowish-brown, crystalline or amorphous powder.
Solubility: Very slightly soluble or practically insoluble in ethanol (96 per cent), practically insoluble in organic solvents. It swells in water but does not dissolve; it dissolves in solutions of alkali hydroxides.
SDS MSDS of Alginic Acid BP Ph Eur EP JP USP NF IP ACS Analytical Reagent FCC Food grade Manufacturers |
