Tricalcium Phosphate or Calcium Phosphate Tribasic Specifications of Commercial Pure & BP Ph Eur USP NF FCC Food Grade Manufacturers & Exporters
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Tricalcium Phosphate or Calcium Phosphate Tribasic CAS Number 7758-87-4 or 1306-06-5 or 12167-74-7 or 62974-97-4
Ca5(OH)(PO4)3 --- 502.31
Calcium hydroxide phosphate CAS 12167-74-7
DEFINITION
Tribasic Calcium Phosphate consists of a variable mixture of calcium phosphates with the approximate composition (10CaO3P2O5-H2O). It contains NLT 34.0% and NMT 40.0% of calcium (Ca).
IDENTIFICATION
A.
Sample solution: Dissolve 100 mg in 5 mL of diluted nitric acid.
Analysis: Warm the Sample solution and add 2 mL ammonium molybdate.
Acceptance criteria: A yellow precipitate is formed.
B.
Analysis: Dissolve the Sample by warming in 10 mL of 2 N hydrochloric acid. Add 2.5 mL of ammonia dropwise, with shaking, and then add 5 mL of ammonium oxalate.
Acceptance criteria: A white precipitate is formed.
Chloride and Sulfate -Chloride:
Standard: 1.0 mL of 0.020 N hydrochloric acid
Sample: 0.500 g of Tribasic Calcium Phosphate
Analysis: Dissolve the Sample in 25 mL of 2 N nitric acid and add 1 mL of silver nitrate.
Acceptance criteria: NMT 0.14%
Chloride and Sulfate -Sulfate:
Standard: 1.0 mL of 0.020 N sulfuric acid
Sample: 0.500 g of Tribasic Calcium Phosphate
Analysis: Dissolve the Sample in the smallest possible amount of 3 N hydrochloric acid. Dilute with water to 100 mL, and filter, if necessary. To 25 mL of the filtrate add 1 mL of barium chloride.
Acceptance criteria: NMT 0.8%
Arsenic: To pass the test. --- 3 ppm
Barium:
Sample: 500 mg of Tribasic Calcium Phosphate
Analysis: Mix the Sample with 10 mL of water, heat, add hydrochloric acid, dropwise, until solution is affected, and then add 2 drops of the acid in excess. Filter, and add to the filtrate 1 mL of potassium sulfate.
Acceptance criteria: No turbidity appears within 15 min.
Carbonate:
Sample: 2 g of Tribasic Calcium Phosphate
Analysis: Mix the Sample with 20 mL of water, and add 3 N hydrochloric acid, dropwise, to effect solution.
Acceptance criteria: No effervescence is produced.
Acid-Insoluble Substances:
Analysis: If an insoluble residue remains in the test for Carbonate, boil the solution, filter, wash the residue well with hot water until the last washing is free from chloride, and ignite the residue to constant weight.
Acceptance criteria: NMT 0.2%; the weight of the residue is NMT 4 mg.
Dibasic Salt and Calcium Oxide: To pass the test.
Limit of Fluoride: To pass the test. --- NMT 75 ppm
Limit of Nitrate: To pass the test.
Water-Soluble Substances: To pass the test. --- NMT 0.5%.
Loss on Ignition:
Analysis: Ignite at 800C for 30 min.
Acceptance criteria: NMT 8.0%
Packaging and Storage: Preserve in well-closed containers.
Specifications of Tribasic Calcium Phosphate BP Ph Eur Grade
Calcium Phosphate BP
CAS 7758-23-8
DEFINITION
Calcium phosphate consists of a mixture of calcium phosphates. It contains not less than 35.0 per cent and not more than the equivalent of 40.0 per cent of Ca (Ar 40.08).
CHARACTERS
A white or almost white powder, practically insoluble in water. It dissolves in dilute hydrochloric acid and in dilute nitric acid.
IDENTIFICATION
A. Dissolve 0.1 g in 5 ml of a 25 per cent V/V solution of nitric acid R. The solution gives reaction (b) of phosphates (2.3.1).
B. It gives reaction (b) of calcium (2.3.1). Filter before adding potassium ferrocyanide solution R.
C. It complies with the limits of the assay.
TESTS
Solution S
Dissolve 2.50 g in 20 ml of dilute hydrochloric acid. If the solution is not clear, filter it. Add dilute ammonia drop-wise until a precipitate is formed. Dissolve the precipitate by adding dilute hydrochloric acid and dilute to 50 ml with distilled water.
Chlorides
Dissolve 0.22 g in a mixture of 1 ml of nitric acid and 10 ml of water and dilute to 100 ml with water. 15 ml of the solution complies with the limit test for chlorides (0.15 per cent).
Fluorides
Not more than 75 ppm of F, determined potentiometrically (2.2.36, Method I) using a fluoride-selective indicator electrode and a silver-silver chloride reference electrode.
Sulphates
Dilute 1 ml of solution S to 25 ml with distilled water 15 ml of the solution complies with the limit test for sulphates (0.5 per cent).
Arsenic
5 ml of solution S complies with limit test A for arsenic (4 ppm).
Iron
Dilute 0.5 ml of solution S to 10 ml with water R. The solution complies with the limit test for iron (400 ppm).
Heavy metals
Dilute 13 ml of solution S to 20 ml with water. 12 ml of the solution complies with limit test A for heavy metals (30 ppm).
Acid-insoluble matter
Dissolve 5.0 g in a mixture of 10 ml of hydrochloric acid and 30 ml of water. Filter, wash the residue with water and dry to constant mass at 100C to 105C. The residue weighs not more than 10 mg (0.2 per cent).
Loss on ignition
Not more than 8.0 per cent, determined on 1.000 g by ignition at 800C for 30 min.
Calcium Phosphate, Tribasic FCC Food Grade
Tricalcium Phosphate; Precipitated Calcium Phosphate
Calcium Hydroxyapatite
Ca3(PO4)2 Formula weight 310.18
Ca5OH(PO4)3 Formula weight 502.31
Ca10(OH)2(PO4)6 Formula weight 1004.61
INS: 341(iii) CAS 7758-87-4
CAS 1306-06-5
CAS 62974-97-4
DESCRIPTION
Calcium Phosphate, Tribasic, occurs as a white powder that is stable in air. It consists of a variable mixture of calcium phosphates. It is insoluble in alcohol and almost insoluble in water, but it dissolves readily in dilute hydrochloric and nitric acids.
Function: Ant caking agent; buffer; nutrient; clouding agent.
REQUIREMENTS
Identification
A. Add ammonium molybdate TS to a warm solution of sample in a slight excess of nitric acid. A yellow precipitate forms.
B. Dissolve about 100 mg of sample by warming it with 5 mL of 2.7 N hydrochloric acid and 5 mL of water; while shaking, add 1 mL of 6 N ammonium hydroxide, drop-wise and then add 5 mL of ammonium oxalate TS. A white precipitate forms.
Assay: Not less than 34.0% and not more than 40.0% of calcium (Ca).
Arsenic: Not more than 3 mg/kg.
Fluoride: Not more than 0.0075%.
Lead: Not more than 2 mg/kg.
Loss on Ignition: Not more than 10.0%.
SDS MSDS of Tricalcium Phosphate or Calcium Phosphate Tribasic BP Ph Eur EP JP USP NF IP ACS Analytical Reagent FCC Food grade Manufacturers |
