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Sodium Stibogluconate or Sodium Antimony Gluconate Specifications of Commercial Pure & BP Ph Eur Grade Manufacturers & Exporters

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Sodium Stibogluconate or Sodium Antimony Gluconate CAS Number 16037-91-5

Sodium Stibogluconate BP Ph Eur Grade Specifications:
CAS 16037-91-5
Action and use: Pentavalent antimony compound; antiprotozoal.

DEFINITION
Sodium Stibogluconate is mainly the disodium salt of µ-oxy-bis[gluconato(3-)-O2, O3,O4-hydroxoantimony]. It contains not less than 30.0% and not more than 34.0% of antimony(V), calculated with reference to the dried and methanol-free substance.

PRODUCTION
The method of manufacture is such as to ensure consistently controlled reaction stoichiometry in order to yield sodium stibogluconate that is satisfactory with regard to intrinsic toxicity.

CHARACTERISTICS
A colourless, mostly amorphous powder.
Very soluble in water; practically insoluble in ethanol (96%) and in ether.

IDENTIFICATION
A. A solution is dextrorotatory.
B. Pass hydrogen sulfide into a 5% w/v solution for several minutes. An orange precipitate is produced.
C. When heated, it chars without melting leaving a residue which yields the reactions characteristic of antimony compounds and the reactions characteristic of sodium salts.

TESTS
Stability and acidity of solution: Heat a solution containing the equivalent of 10% w/v of antimony(V) in an autoclave at 115.5C and at a pressure of 70 kPa for 30 minutes. The resulting solution is colourless or almost colourless and has a pH of 5.0 to 5.6.
Antimony(III): Dissolve 2 g in 30 mL of water, add 15 ;mL of hydrochloric acid and titrate with 0.00833M potassium bromate using methyl orange solution as indicator. Not more than 1.3 mL of 0.00833M potassium bromate is required.
Chloride: Dissolve 2.5 g in 50 mL of water and add 2 mL of 2M nitric acid and 75 mL of acetate buffer pH 5.0. Titrate with 0.1M silver nitrate determining the end point potentiometrically. Not more than 3.0 ;mL of 0.1M silver nitrate is required.
Methanol: Not more than 2.0% w/w when determined by the following method. Carry out the method for gas chromatography, using the following solutions. For solution (1) add 1 mL of a 1.0% v/v solution of methanol to 5 mL of a 0.2% v/v solution of absolute ethanol (internal standard). For solution (2) add 5 mL of water to 0.5 g of the substance being examined and mix with the aid of ultrasound until solution is complete. For solution (3) add 5 mL of a 0.2% v/v solution of the internal standard to 0.5 g of the substance being examined and mix with the aid of ultrasound until solution is complete.
The chromatographic procedure may be carried out using a glass column (1.5 m × 4 mm) packed with porous polymer beads (80 to 100 mesh) (Porapak Q and Chromosorb 101 are suitable) and maintained at 130C.
Calculate the percentage w/w of methanol taking 0.792 g as its weight per mL at 20C.
Loss on drying: When dried to constant weight at 130C at a pressure not exceeding 0.7 kPa, loses not more than 15.0% of its weight. Use 1 g.

SDS MSDS of Sodium Stibogluconate or Sodium Antimony Gluconate BP Ph Eur EP JP USP NF IP ACS Analytical Reagent FCC Food grade Manufacturers

Crystal Clear Products and the group companies are manufacturing chemicals since several decades. We have automatic vacuum operated titanium evaporators and SS316 equipments to produce top grade of chemical products. We have toll manufacturers and representatives in China, UAE, Europe, Canada & USA and agents & customers in all countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Bangkok Thailand, Kaula Lumpur Malaysia, Dubai UAE etc. & sales representative in Chicago, Houston New York & Los Angeles, USA. Associated units are FDA-GMP certified, Halal and/or Kosher certified, REACH registered, ISO-9001, ISO-22000 HACCP certified, Crisil Rated.

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Crystal Clear Products
Plot No-C1-1031-9, GIDC Estate, Panoli, Ankleshwar, Gujarat - 393002. India
Telephone Mobile: 91-7506449333; e-mail: info@crystalclearproducts.org

e-mail: info@crystalclearproducts.org

Manufacturers, Suppliers of IP BP Ph Eur EP JP USP NF FCC Food, ACS Reagent GMP Grades of Chemicals like Sodium Stibogluconate or Sodium Antimony Gluconate